IN THE FIRST OF A TWO-PART ARC, PHLOX'S SKILLS AS A DOCTOR BRING HIM UNWANTED ATTENTION BY THE KLINGONS, WHILE TRIP LEAVES ENTERPRISE TO JOIN THE CREW OF A NEW STARSHIP, ON "STAR TREK: ENTERPRISE," FRIDAY, FEB. 18

Seth MacFarlane ("Family Guy") Guest Stars as Ensign Rivers, James Avery ("The Fresh Prince of Bel-Air") Guest Stars as Klingon General K�Vagh and John Schuck ("Star Trek IV") Guest Stars as Klingon Scientist Antaak

"Affliction" -- On Earth, Dr. Phlox is kidnapped by a band of Klingons, desperate to find a cure for a genetically-engineered virus that threatens their entire race, and Trip begins his new assignment aboard the starship Columbia as it prepares to embark on its maiden voyage, on STAR TREK: ENTERPRISE, Friday, Feb. 18 (8:00-9:00 PM, ET/PT) on UPN. Michael Grossman directed the episode written by Mike Sussman from a story by Manny Coto.

This arc reveals the beginnings of a second, smooth-headed breed of Klingon, seen in the original "Star Trek" series.

Meanwhile, Reed's ties to a mysterious intelligence organization compromises his allegiance to Archer and Enterprise. Later, T'Pol attempts her first mind-meld in the search for clues to Phlox's whereabouts.

Captain Jonathan Archer: Scott Bakula
Chief Engineer Charles Tucker III: Connor Trinneer
Vulcan Sub Commander T'Pol: Jolene Blalock
Lt. Malcolm Reed: Dominic Keating
Ensign Travis Mayweather: Anthony Montgomery
Ensign Hoshi Sato: Linda Park
Dr. Phlox: John Billingsley
Antaak: John Schuck
General K'Vagh: James Avery
Klingon Prisoner: Marc Worden
Alien #1: Brad Greenquist
Lt. Collins: Kate McNeil
Captain Erika Hernandez: Ada Maris
Ensign Rivers: Seth MacFarlane
Harris: Eric Pierpoint
Marab: Terrell Tilford
Kelby: Derek Magyar

RATING: To Be Announced