IZZIE�S ANGER AT THE PHILANDERING ALEX GETS THE BEST OF HER, ON ABC�S �GREY�S ANATOMY�

Rosanna Arquette Guest Stars

�Owner of a Lonely Heart� � Cristina Yang has little sympathy for Constance Ferguson (special guest star Rosanna Arquette), a prison inmate who jeopardizes her health just to get out of solitary confinement. Meanwhile the interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges, Izzie�s anger at Alex reaches boiling point, and Dr. Addison Shepherd decides to teach Izzie a very painful lesson, on �Grey�s Anatomy,� SUNDAY, DECEMBER 4 (10:01-11:00 p.m., ET) on the ABC Television Network.

�Grey�s Anatomy� stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Isaiah Washington as Preston Burke, Katherine Heigl as Isobel �Izzie� Stevens, Justin Chambers as Alex Karev, T.R. Knight as George O�Malley, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, and Kate Walsh as Addison Shepherd.

Guest starring is Rosanna Arquette as Constance Ferguson. Other guest cast TBA.

�Owner of a Lonely Heart� was written by Mark Wilding and was directed by Dan Minahan.

�Grey�s Anatomy� is broadcast in 720 Progressive (720P), ABC�s selected HDTV format, with 5.1-channel surround sound and Spanish subtitles via secondary closed captioning.

A TV parental guideline will be assigned closer to airdate.