PA: Due to some graphic content, viewer discretion is advised.

A TEENAGE HEART TRANSPLANT PATIENT IS RUSHED TO THE HOSPITAL WHEN SHE HAS AN ALLERGIC REACTION WHILE LIVING IN A "CLEAN" ROOM, AND HOUSE AND WILSON WORK OUT THE KINKS OF THEIR NEW LIVING ARRANGEMENT ON "HOUSE" TUESDAY, APRIL 4, ON FOX

Michelle Trachtenberg and Mel Harris Guest-Star

Melinda (guest star Michelle Trachtenberg), a rebellious teenage girl who's immunocompromised as a result of medications she's taking after a heart transplant, has a severe allergic reaction and goes into shock despite living in a "clean" room. House and the team step in to figure out exactly what caused the reaction, but end up playing referee between Melinda, her overprotective mother (guest star Mel Harris) and her boyfriend. Melinda's heart condition worsens and she develops a paralysis that is slowly moving up her legs, and the team must rush to solve her case before the paralysis reaches her heart. Meanwhile, House and Wilson continue to work out the kinks in their new living arrangement in the "Safe" episode of HOUSE airing Tuesday, April 4 (9:00-10:00 PM ET/PT) on FOX. (HOU-216) (TV-14 D, L)

Cast: Hugh Laurie as Dr. Gregory House; Lisa Edelstein as Dr. Lisa Cuddy; Omar Epps as Dr. Eric Foreman; Robert Sean Leonard as Dr. James Wilson; Jennifer Morrison as Dr. Allison Cameron; Jesse Spencer as Dr. Robert Chase.

Guest Cast: Michelle Trachtenberg as Melinda; Mel Harris as Barbara; Lance Guest as Lewis; Jake McDorman as Dan.