DON AND HIS TEAM HUNT DOWN A 30-YEAR-OLD TEACHER AND HER 17-YEAR- OLD BOYFRIEND WHO ARE ON A CRIME SPREE FROM INDIANA TO LOS ANGELES, ON PART ONE OF A TWO-PART THIRD SEASON PREMIERE OF "NUMB3RS," FRIDAY, SEPT. 22 ON THE CBS TELEVISION NETWORK

Lou Diamond Phillips ("La Bamba") Returns, Kim Dickens ("Deadwood") and David Gallagher ("7th Heaven") Guest Star

"Spree" -- While Don and his team are faced with trying to capture a 30-year-old teacher (Dickens) and her 17-year-old boyfriend/student (Gallagher) who are on a violent cross-country crime spree, one of their own gets caught in the crossfire, on part one of a two-part third season premiere of NUMB3RS, Friday, Sept. 22 (10:00-11:00 PM, ET/PT) on the CBS Television Network. John Behring directed the episode written by Ken Sanzel.

Lou Diamond Phillips ("La Bamba") returns as Agent Ian Edgerton. Kim Dickens ("Deadwood") and David Gallagher ("7th Heaven") guest star on this episode.

Meanwhile, after Charlie and Amita share an intimate moment, he freaks out when he thinks Amita has accepted a teaching position at CalSci to be with him.

Later, Alan decides he is ready to find a place of his own.

NUMB3RS is a drama about an FBI agent who recruits his mathematical-genius brother to help the Bureau solve a wide range of challenging crimes in Los Angeles. The two brothers take on the most confounding criminal cases from a very distinctive perspective. Inspired by actual events, the series depicts how the confluence of police work and mathematics provides unexpected revelations and answers to the most perplexing criminal questions. A dedicated FBI agent, Don Eppes, couldn't be more different from his younger brother, Charlie Eppes, a brilliant mathematician who, since he was little, yearned to impress his big brother. Don is joined on his team by fellow agents Megan Reeves, a behavioral specialist who brings psychological insight to their investigations; David Sinclair, who utilizes his incredible perspective and the survival skills he learned growing up in the Bronx; and new agent Colby Granger who just completed an extensive tour of duty in the U.S. Military. After some initial reluctance, Don's team welcomes Charlie's innovative methods to crime-solving. Their father, Alan, is happy to see his sons working together even though he doesn't understand the intricacies of what Charlie does for a living. It is his co-workers at CalSci who further refine Charlie's approach and help him stay focused. Physicist friend Dr. Larry Fleinhardt constantly challenges Charlie to employ a broader point of view to his work with the FBI, and Amita Ramanjuan, Charlie's former grad student frequently helps him see cases in a new light Despite their disparate approaches to life, Don and Charlie are able to combine their areas of expertise and solve some killer cases.

NUMB3RS is produced by Scott Free Productions, in association with CBS Paramount Network Television. Ridley Scott, Tony Scott, Barry Schindel, Nick Falacci, Cheryl Heuton and David W. Zucker are the executive producers.

SERIES REGULARS:

Don Eppes: Rob Morrow
Charlie Eppes: David Krumholtz
Alan Eppes: Judd Hirsch
David Sinclair: Alimi Ballard
Larry Fleinhardt: Peter MacNicol
Megan Reeves: Diane Farr
Amita Ramajuan: Navi Rawat
Colby Granger: Dylan Bruno

RECURRING:

Agent Ian Edgerton: Lou Diamond Phillips

GUEST STARS:

Crystal Hoyle: Kim Dickens
Buck Winters: David Gallagher
Pierce Brenner: Jerry O'Donnell
Felix: Andy Mackenzie
Meth Chemist #1: Colin Campbell
Lydia Campos: Georgia Hatzis

RATING: To Be Announced