IZZIE FACES HER PAINFUL PAST WITH GEORGE BY HER SIDE, DEREK AND MEREDITH QUESTION THEIR RELATIONSHIP, AND ALEX GROWS INCREASINGLY ATTACHED TO HIS PATIENT, ON ABC'S "GREY'S ANATOMY"

Mare Winningham Returns as Susan Grey

Elizabeth Reaser ("Sweet Land") and Roger Rees ("The Prestige") Return as Jane Doe and Dr. Colin Marlow

"Time After Time" � Izzie faces her past and finds comfort in George, while Alex becomes more attached to Jane Doe (Elizabeth Reaser), Meredith and Derek question their own status, and Cristina resolves to fight for her relationship with Burke -- despite her past with Colin Marlow (Roger Rees) -- on "Grey's Anatomy," THURSDAY, APRIL 19 (9:00-10:01 p.m., ET) on the ABC Television Network.

Editors note: This program will repeat Friday, April 20 (8:00-9:01 p.m., ET).

"Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Isaiah Washington as Preston Burke, Katherine Heigl as Isobel "Izzie" Stevens, Justin Chambers as Alex Karev, T.R. Knight as George O'Malley, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Kate Walsh as Addison Shepherd, Sara Ramirez as Callie Torres and Eric Dane as Mark Sloan.

Guest starring Elizabeth Reaser as Jane Doe, Roger Rees as Dr. Colin Marlowe, Dee Wallace as Joan Waring, Brent Jennings as Charles, Suzanne Cryer as Caroline Klein, Tim Hopper as Dustin Klein, Marc Vann as hematologist, Steven W. Bailey as Joe, with Mare Winningham as Susan Grey

"Time After Time" was written by Stacy McKee and directed by Christopher Misiano.

"Grey's Anatomy" is broadcast in 720 Progressive (720P), ABC's selected HDTV format, with 5.1-channel surround sound and Spanish audio via SAP.

A TV parental guideline will be posted closer to airdate.