PA: Viewer discretion is advised.

FOREMAN HANDS IN HIS RESIGNATION WHILE THE TEAM RACES TO DIAGNOSE A YOUNG COLLEGE STUDENT ON "HOUSE" TUESDAY, MAY 8, ON FOX

Piper Perabo Guest-Stars

Addie, a 19-year-old college student, is admitted to Princeton Plainsboro after coughing up a mouthful of blood during karate class. Before treating the patient, Foreman unapologetically informs the rest of the team that he is resigning, but will not say why. House strongly believes an infection is to blame for Addie's bleeding, even though her symptoms indicate otherwise. When Addie's lungs suddenly fill with fluid, the team believes that cancer or toxins could be an underlying cause, but House refuses to stray from his initial infection diagnosis. As Addie's condition worsens, House suggests a risky life-or-death treatment to confirm his suspected diagnosis, leaving the team wondering whether he cares more about making a diagnosis than he does about saving Addie's life. Meanwhile, House takes a special interest in a young, attractive nutritionist named Honey (guest star Piper Perabo), who accompanied her boyfriend to the clinic for treatment. Knowing he will have a position open soon on his team, House has Honey fill out an employment application and sees to it they meet again under more casual circumstances in the "Resignation" episode of HOUSE airing Tuesday, May 8 (9:00-10:00 PM ET/PT) on FOX. (HOU-322) (TV-14 L)

Cast: Hugh Laurie as Dr. Gregory House; Lisa Edelstein as Dr. Lisa Cuddy; Omar Epps as Dr. Eric Foreman; Robert Sean Leonard as Dr. James Wilson; Jennifer Morrison as Dr. Allison Cameron; Jesse Spencer as Dr. Robert Chase.

Guest Cast: Lyndsy Fonseca as Addie; Tony Spiridakis as Ben; Eve Gordon as Jody; Piper Perabo as Honey; Tracy Howe as Steve; Shonda Farr as Jamie; Bayani Ison as Sensei; Wayne Sable as Kyle; Kwabena Darkwah as Daniel; Bobbin Bergstrom as Nurse.