AN AMBULANCE CRASH ENDANGERS THE LIVES OF THE PARAMEDICS INVOLVED, AS MEREDITH AND THE CHIEF WORK ON-SITE TO SAVE THEM, IN THE FIRST EPISODE OF A TWO-PARTER OF ABC'S "GREY'S ANATOMY"

Seth Green ("Austin Powers," "Robot Chicken") Guest Stars as Nick

Emmy-Nominee Elizabeth Reaser Returns as Ava

"Crash Into Me -- Part One" � An ambulance crash endangers the lives of the paramedics involved, as Meredith and the Chief work on-site to save them, Bailey treats a patient who refuses her help, and Ava returns for Alex and meets his other girlfriend in the process, on "Grey's Anatomy," THURSDAY, NOVEMBER 22 (9:00-10:02 p.m., ET) on the ABC Television Network.

"Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Katherine Heigl as Isobel "Izzie" Stevens, Justin Chambers as Alex Karev, T.R. Knight as George O'Malley, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Chyler Leigh as Lexie Grey, and Brooke Smith as Erica Hahn.

Guest cast: tba.

"Crash Into Me" was written by Krista Vernoff and Shonda Rhimes and directed by Michael Grossman.

"Grey's Anatomy" is broadcast in 720 Progressive (720P), ABC's selected HDTV format, with 5.1-channel surround sound and Spanish audio via SAP. A TV parental guideline will be posted closer to airdate.

This episode of "Grey's Anatomy" will be available on ABC.com the day after airing on the network for users to watch online.