Air Date: Friday, February 22, 2008
Time Slot: 9:00 PM-10:00 PM EST on ABC
Episode Title: "WHAT WOULD YOU DO?"
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A Special Edition of "20/20" at 9:00 p.m. Examines Rare Medical Conditions and Cases

At 10:00 p.m.: When People Encounter a Situation That Cries Out for Action, Do They Step in, Back Away or Just Walk on By?

A special edition of "20/20" reports on some of the strangest cases known to medicine, including a syndrome that gives its sufferers complete -- and fatal � insomnia and a condition that causes continuous and unwanted sexual arousal in women. Viewers can also take their turn at diagnosis with a "You Be the Doctor" segment that allows them to vote online during the show. The "20/20: Medical Mysteries" hour airs on FRIDAY, FEBRUARY 22 from 9:00-10:00 p.m., ET on the ABC Television Network. Immediately following at 10:00 p.m., "20/20" previews the upcoming newsmagazine limited series "Primetime: What Would You Do?"

9:00 p.m. reports include:

� A hereditary sleeping syndrome that researches say goes back over 250 years, Fatal Familial Insomnia is an extremely rare genetic disorder that steals victims' sleep, their minds -- and then their lives. It begins in midlife with occasional insomnia, but as the disorder progresses, they live in a zombie-like state for months before dying. For Carolyn and Cheryl, the genetic mutation has killed their grandfather, their uncle and even their mother. Do they carry the gene themselves? Jay Schadler reports.

� Imagine being a woman constantly on the edge of orgasm. Sound like fun? Think again. John Qui�ones reports on four women who suffer from a mysterious condition called Persistent Sexual Arousal Syndrome -- or PSAS. First identified just a few years ago, the syndrome causes continuous and unwanted sexual arousal, and those who have it say it's a nightmare. "20/20" reports on what causes PSAS, whether it can be cured and the effect it has on these women's lives.

� Shiloh Pepin was born with her legs fused together, feet turned outward -- a condition called sirenomelia, or "Mermaid Syndrome" -- that is almost always fatal to a newborn. What is it like to defy the odds and survive, even after more than 100 surgeries? "20/20" brings together two of only three people in the world known to have survived this condition -- alive against all odds. Bob Brown reports.

� Throughout the hour there will be clues to another new medical mystery designed to let the viewer find the diagnosis. The interactive segment, entitled "You Be the Doctor," will allow viewers to vote online for a diagnosis for little Evan -- a baby with alarming symptoms that seem to be killing him. Doctors try test after test -- will you get to the diagnosis before they do? At the end of the show, the audience will learn if they were right, and what Evan was actually suffering from.

"20/20" at 10:00 p.m.:

Facing Ethical Dilemmas, What Would You Do?

When people see a situation that calls for action, do they step in or back away? The 10:00 p.m. hour of "20/20" previews the upcoming newsmagazine limited series "Primetime: What Would You Do?" Using hidden cameras, the program creates everyday scenarios and then captures people's reactions. Whether people are compelled to act or mind their own business, John Qui�ones reports on their split-second -- and often surprising -- decision-making process. Friday's scenarios include:

� When three teens are trashing someone's parked car in broad daylight, will anyone in the neighborhood intervene? Will there be a difference if the vandals are black or white?

� Imagine being out to dinner one night when you notice a playful and flirtatious couple. On a closer look, you notice that the man is your good friend's husband. The woman he's with is a complete stranger. Do you tell your friend?

� When a thief works a crowded bar and lifts a wallet from the purse of an unsuspecting woman, many patrons see him in the act. Will anyone intervene?

"20/20" is anchored by Elizabeth Vargas and John Stossel. David Sloan is executive producer.

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