SHELDON AND AMY BREAK UP, ON "THE BIG BANG THEORY," THURSDAY, OCT. 7

Laurie Metcalf Reprises Her Role as Sheldon's Mother

"The Zazzy Substitution" - The guys are concerned as Sheldon searches for an alternative to human companionship, on THE BIG BANG THEORY, Thursday, Oct. 7 (8:00-8:31 PM, ET/PT) on the CBS Television Network.

SERIES REGULARS:

Leonard................................... Johnny Galecki
Sheldon......................................... Jim Parsons
Penny.......................................... Kaley Cuoco
Wolowitz.................................. Simon Helberg
Koothrappali ............................. Kunal Nayyar

GUEST CAST:

Mary......................................... Laurie Metcalf
Amy............................................ Mayim Bialik

STORY BY: Chuck Lorre & Bill Prady & Jim Reynolds

TELEPLAY BY: Lee Aronsohn & Steven Molaro & Maria Ferrari

DIRECTED BY: Mark Cendrowski

RATING: To Be Announced