"UP ALL NIGHT"
09/14/2011 (10:00PM - 10:30PM) (Wednesday) : SERIES PREMIERE - REAGAN AND CHRIS ADJUST TO LIFE WITH THEIR NEWEST ADDITION - Determined not to compromise her career or cool reputation to the clich�s of motherhood, Reagan Brinkley (Christina Applegate) adjusts to life with a baby and returns to work with the support of her stay-at-home husband, Chris (Will Arnett). As if motherhood weren't enough, as a talk-show executive producer, Reagan must also tend to the endless needs of her friend and boss Ava (Maya Rudolph), an ambitious but vulnerable talk-show host. Nick Cannon stars as Ava's charismatic co-host "Calvin" and Jennifer Hall stars as Ava's long-suffering assistant "Missy." Matt Lauer guest stars.