RICHARD CELEBRATES HIS 10,000th SURGERY, AND DEREK AND LEXIE TAKE ON A CASE PREVIOUSLY DEEMED INOPERABLE, ON ABC'S "GREY'S ANATOMY"

Emmy Award Winner Loretta Devine Returns as Adele Webber , And Nia Vardalos ("My Big Fat Greek Wedding") and Peri Gilpin ("Frasier") Guest Star

"Hope for the Hopeless" - Richard performs his 10,000th surgery on a pair of bickering sisters (Nia Vardalos and Peri Gilpin) who come into the hospital for a liver transplant; Derek and Lexie take on a neuroblastoma case that has been previously deemed inoperable; Teddy and Cristina cross the line when they go against Owen's orders and try to steal a case from Alex and Dr. McQueen; Ellis Grey's shadow looms as Meredith searches for a specialty; meanwhile Adele is brought into the hospital after she is found wandering the streets, on Grey's Anatomy, THURSDAY, JANUARY 19 (9:00-10:02 p.m., ET) on the ABC Television Network.

"Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Chyler Leigh as Lexie Grey, Kevin McKidd as Owen Hunt, Jessica Capshaw as Arizona Robbins, Kim Raver as Teddy Altman, Jesse Williams as Jackson Avery and Sarah Drew as April Kepner.

Guest cast TBA.

"Hope for the Hopeless" was written by Peter Nowalk and directed by Mark Jackson.

"Grey's Anatomy" is broadcasted in 720 Progressive (720P), ABC's selected HTV format, with 5.1-channel surround sound. A TV parental guideline will be assigned closer to airdate.

For more information on "Grey's Anatomy" please visit ABC.com.