AGENT MAY'S LIFE HANGS IN THE BALANCE, ON 'MARVEL'S AGENTS OF S.H.I.E.L.D.'

"Uprising" - As Coulson, Mack and Fitz attempt to track down and neutralize a rogue group looking to end Inhuman Registration worldwide, Simmons and Dr. Radcliffe only have hours to save May before she succumbs forever to her mysterious illness, on "Marvel's Agents of S.H.I.E.L.D.," TUESDAY, OCTOBER 11 (10:00-11:00 p.m. EDT), on the ABC Television Network.

"Marvel's Agents of S.H.I.E.L.D." stars Clark Gregg as Agent Phil Coulson, Ming-Na Wen as Agent Melinda May, Chloe Bennet as Daisy Johnson, Iain De Caestecker as Agent Leo Fitz, Elizabeth Henstridge as Agent Jemma Simmons and Henry Simmons as Agent Alphonso "Mack" MacKenzie.

Guest starring are John Hannah as Holden Radcliffe, Natalia Cordova-Buckley as Elena "Yo-Yo" Rodriguez, Jason O'Mara as the Director, Gabriel Luna as Robbie Reyes, Mallory Jansen as Aida, Parminder Nagra as Senator Rota Nadeer, Alexander Wraith as Agent Anderson, Lorenzo James Henrie as Gabe Reyes, Patrick Cavanaugh as Burrows, Ricky Saenz as pistol punk, Devon Libran as slugger punk, Valery Ortiz as Maria, Derek Hughes as The Amazing Mertz, Preston Flagg as Darryl, Stephanie Maura Sanchez as bridesmaid #1, Jen Kuo Sung as Chen, Dale Pavinski as Briggs, Michael Cory Davis as agitator, Aaron Gaffrey as mystery figure and Adriana Diaz as hostage.

"Uprising" was written by Craig Titley and directed by Magnus Martens.

"Marvel's Agents of S.H.I.E.L.D." is broadcast in 720 Progressive (720P), ABC's selected HDTV format with a 5.1 channel surround sound. A TV parental guideline will be assigned closer to the airdate.